Endoplasmic reticulum–mitochondria contacts: function of …

The characterization of dynamic contacts that form between the endoplasmic reticulum and mitochondria have highlighted the different ways in which the functions of these organelles can be coordinated.

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Endoplasmic Reticulum Stress Mediates Vascular Smooth …

Endoplasmic reticulum (ER) stress-mediated extracellular vesicle (EV) release and Grp78 (glucose-regulated protein, 78 kDa) deposition in the ECM (extracellular matrix) promote vascular smooth muscle cell (VSMC) calcification. ER stress induces loading of Grp78 into EVs. Warfarin induces the PERK (PKR [protein kinase RNA]-like …

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Ablation of ERO1A induces lethal endoplasmic reticulum

Liu et al. reveal that ERO1A mediates an immune-suppressive TME and attenuates the response to PD-1 blockade by impairing the balance between IRE1α and PERK signaling activities and induces lethal unfolded protein responses. They find that targeting ERO1A can incite anti-tumor immunity and enhance aPD-1 efficacy in …

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A model for the generation and interconversion of ER

The structure of the ER not only differs among cell types, but also can change over the course of the cell cycle and during differentiation ().For example, in Xenopus egg extracts, Caenorhabditis elegans, and some tissue culture cells, ER tubules convert into sheets during mitosis (10–13), and ER sheets accumulate and form stacks …

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The Structure and Function of the Endoplasmic …

The endoplasmic reticulum is a network of tubules and flattened sacs that serve a variety of functions in plant and animal cells . The two regions of the ER differ in both structure and function. Rough ER …

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Endoplasmic reticulum

The endoplasmic reticulum (ER) is a compartment (organelle) in eukaryotic cells that consists of membrane sacs called cisternae. Because of the bound ribosomes, the 'rough' ER is the site of ...

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The Endoplasmic Reticulum and Golgi Body: What's the …

Similarly, the ER comprises an extensive network of membrane-enclosed sacs and tubules. It has such a physically wide reach that in most eukaryotic cells, it is the largest organelle. It also has ...

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Discovery of endoplasmic reticulum calcium stabilizers to rescue ER

The ER plays important roles in folding, posttranslational modification, and trafficking of newly synthesized secretory and membrane proteins. Protein folding is aided by ER-resident molecular chaperones and enzymes, such as Ig binding protein (BiP), calnexin, calreticulin, and protein disulfide isomerase (6, 7). Disturbance to ER …

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Prolonged Endoplasmic Reticulum Stress in Hypertrophic …

The endoplasmic reticulum (ER) is recognized as an organelle that participates in the folding of secretory and membrane proteins. 1,2 Histological examination has demonstrated that the ER develops markedly in hypertrophic and failing hearts. 3,4 It has been reported that the synthesis of secretory proteins, such as atrial natriuretic peptide (ANP) and brain …

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